COVID-19 Host Genetics Initiative on Twitter: "Time to meet another gene, er, three. View OAS1, OAS2, and OAS3 on chromosome 12 in our results browser (works best in Chrome) https://t.co/urUQssqRnv #DNADay2021 #HGIDNADay #
![Comparing Expression of OAS-RNaseL Pathway-Related Genes in SARS-CoV-2 and Similar Viruses | bioRxiv Comparing Expression of OAS-RNaseL Pathway-Related Genes in SARS-CoV-2 and Similar Viruses | bioRxiv](https://www.biorxiv.org/content/biorxiv/early/2021/04/30/2021.04.29.442063/F1.large.jpg)
Comparing Expression of OAS-RNaseL Pathway-Related Genes in SARS-CoV-2 and Similar Viruses | bioRxiv
![OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte Proliferation by Regulating Cell Cycle and Augmenting IFN-1‒Induced Jak1‒Signal Transducer and Activator of Transcription 1 Phosphorylation in Psoriasis - ScienceDirect OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte Proliferation by Regulating Cell Cycle and Augmenting IFN-1‒Induced Jak1‒Signal Transducer and Activator of Transcription 1 Phosphorylation in Psoriasis - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0022202X22002044-fx1.jpg)
OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte Proliferation by Regulating Cell Cycle and Augmenting IFN-1‒Induced Jak1‒Signal Transducer and Activator of Transcription 1 Phosphorylation in Psoriasis - ScienceDirect
![All About the RNA: Interferon-Stimulated Genes That Interfere With Viral RNA Processes | Semantic Scholar All About the RNA: Interferon-Stimulated Genes That Interfere With Viral RNA Processes | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/47b29a0f21bb46bdf709941eef9a4c16081230b9/2-Figure1-1.png)
All About the RNA: Interferon-Stimulated Genes That Interfere With Viral RNA Processes | Semantic Scholar
![Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses | PNAS Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses | PNAS](https://www.pnas.org/cms/10.1073/pnas.1519657113/asset/0087092f-2f3e-46d6-a05e-e1e0451a4d76/assets/graphic/pnas.1519657113fig08.jpeg)
Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses | PNAS
![Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses | PNAS Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses | PNAS](https://www.pnas.org/cms/10.1073/pnas.1519657113/asset/5ae70cbb-7a55-4aec-99b6-166450b2b3ec/assets/graphic/pnas.1519657113sfig01.jpeg)
Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses | PNAS
![Exon / intron structure of OAS3 and OASL genes. Exons are marked by... | Download Scientific Diagram Exon / intron structure of OAS3 and OASL genes. Exons are marked by... | Download Scientific Diagram](https://www.researchgate.net/publication/12236308/figure/fig7/AS:277066504261633@1443069210061/Exon-intron-structure-of-OAS3-and-OASL-genes-Exons-are-marked-by-coloured-bars-and.png)
Exon / intron structure of OAS3 and OASL genes. Exons are marked by... | Download Scientific Diagram
![Suppressing PARylation by 2′,5′‐oligoadenylate synthetase 1 inhibits DNA damage‐induced cell death | The EMBO Journal Suppressing PARylation by 2′,5′‐oligoadenylate synthetase 1 inhibits DNA damage‐induced cell death | The EMBO Journal](https://www.embopress.org/cms/asset/a31c300a-c5ae-47b5-9699-660dc8819151/embj2019101573-abs-0001-m.jpg)
Suppressing PARylation by 2′,5′‐oligoadenylate synthetase 1 inhibits DNA damage‐induced cell death | The EMBO Journal
![Origin and development of oligoadenylate synthetase immune system | BMC Ecology and Evolution | Full Text Origin and development of oligoadenylate synthetase immune system | BMC Ecology and Evolution | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs12862-018-1315-x/MediaObjects/12862_2018_1315_Fig1_HTML.png)
Origin and development of oligoadenylate synthetase immune system | BMC Ecology and Evolution | Full Text
![IJMS | Free Full-Text | Expression of the OAS Gene Family Is Highly Modulated in Subjects Affected by Juvenile Dermatomyositis, Resembling an Immune Response to a dsRNA Virus Infection IJMS | Free Full-Text | Expression of the OAS Gene Family Is Highly Modulated in Subjects Affected by Juvenile Dermatomyositis, Resembling an Immune Response to a dsRNA Virus Infection](https://www.mdpi.com/ijms/ijms-19-02786/article_deploy/html/images/ijms-19-02786-g006.png)
IJMS | Free Full-Text | Expression of the OAS Gene Family Is Highly Modulated in Subjects Affected by Juvenile Dermatomyositis, Resembling an Immune Response to a dsRNA Virus Infection
![OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids | Nature Reviews Immunology OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids | Nature Reviews Immunology](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fnri3719/MediaObjects/41577_2014_Article_BFnri3719_Fig1_HTML.jpg)
OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids | Nature Reviews Immunology
![Genetic predisposition in the 2′-5′A pathway in the development of type 1 diabetes: potential contribution to dysregulation of innate antiviral immunity | SpringerLink Genetic predisposition in the 2′-5′A pathway in the development of type 1 diabetes: potential contribution to dysregulation of innate antiviral immunity | SpringerLink](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs00125-021-05469-5/MediaObjects/125_2021_5469_Fig1_HTML.png)
Genetic predisposition in the 2′-5′A pathway in the development of type 1 diabetes: potential contribution to dysregulation of innate antiviral immunity | SpringerLink
![Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production - ScienceDirect Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S1074761318305612-fx1.jpg)
Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production - ScienceDirect
![Recurrent Loss-of-Function Mutations Reveal Costs to OAS1 Antiviral Activity in Primates - ScienceDirect Recurrent Loss-of-Function Mutations Reveal Costs to OAS1 Antiviral Activity in Primates - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S1931312819300381-fx1.jpg)
Recurrent Loss-of-Function Mutations Reveal Costs to OAS1 Antiviral Activity in Primates - ScienceDirect
![Viruses | Free Full-Text | 2′, 5′-Oligoadenylate Synthetase 2 (OAS2) Inhibits Zika Virus Replication through Activation of Type Ι IFN Signaling Pathway Viruses | Free Full-Text | 2′, 5′-Oligoadenylate Synthetase 2 (OAS2) Inhibits Zika Virus Replication through Activation of Type Ι IFN Signaling Pathway](https://pub.mdpi-res.com/viruses/viruses-12-00418/article_deploy/html/images/viruses-12-00418-g007.png?1588960835)
Viruses | Free Full-Text | 2′, 5′-Oligoadenylate Synthetase 2 (OAS2) Inhibits Zika Virus Replication through Activation of Type Ι IFN Signaling Pathway
![Activation of RNase L in Egyptian Rousette Bat-Derived RoNi/7 Cells Is Dependent Primarily on OAS3 and Independent of MAVS Signaling | mBio Activation of RNase L in Egyptian Rousette Bat-Derived RoNi/7 Cells Is Dependent Primarily on OAS3 and Independent of MAVS Signaling | mBio](https://journals.asm.org/cms/10.1128/mbio.02414-19/asset/c0b5a0e1-16fd-4d44-a5fd-ce4f3c1aa642/assets/graphic/mbio.02414-19-f0001.jpeg)